SAMe (S-Adenosyl-Methionine)

Anti-Depressant and Liver Protector

SAMe is a “methyl donor” manufactured in the brain from the amino acid methionine. SAMe is involved in the production of serotonin and dopamine. Levels of SAMe are found to be impaired in depressed patients, and oral doses are effective in improving these neurotransmitter levels. SAMe has also been found beneficial for osteoarthritis, particularly of the knee.

SAMe supplementation is useful for:

• depression
• low serotonin and/or dopamine levels
• liver cell regeneration
• fatty liver
• cirrhosis
• high cholesterol
• osteoarthritis

Dosage:

Depression -- Four hundred milligrams, three to four times daily. Start at a dosage of 200 milligrams twice daily for the first day. Increase to 400 milligrams twice daily on day three, 400 milligrams three times daily on day ten, and finally to the full dosage of 400 milligrams four times daily after 20 days, if required.

Osteoarthritis -- Follow the guidelines for depression. After 21 days at a dosage of 1,200 milligrams daily, reduce dosage to a maintenance dosage (minimum dosage required to alleviate symptoms), usually 200 milligrams a day.

Fibromyalgia -- Two hundred milligrams to four hundred milligrams, two times daily.

Liver Disorders -- Two hundred milligrams to four hundred milligrams, two to three times daily.

Migraine Headaches --Two hundred milligrams to four hundred milligrams, two times daily (Requires long term use for maximum effectiveness).

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References:

1.) Baldessarini RJ, Neuropharmacology of S-adenosyl-L-methionine. Am J Med 83 (Suppl. 5A), 95-103, 1987.
2.) Reynolds E, Carney M, and Toone B. Methylation and mood. Lancet ii, 196-199, 1983.
3.) Salmaggi P. et al., Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women. Psychother Psychosom 59, 34-40, 1993.
4.) Kagan BL, et al., Oral S-adenosylmethionine in depression: A randomized, double-blind placebo-controlled trial. Am J Psychiatry 147, 591-595, 1990.
5.) Floman, Y., Eyre, D.R., and Glimcher, MJ., Induction of Osteoarthritis in the Rabbit Knee Joint: Biochemical Studies on the Articular Cartilage Clinical Orthopaedics &f Related Research (March-April 1980): (147): 278-86.
6.) Thompson, R. C.,Jr., and Oegema, T.R.,Jr., Metabolic Activity of Articular Cartilage in Osteoarthritis, an In-Vitro Study Journal of Bone &f Joint Surgeryó American Volume (April 1979): 61 (3): 407-16.
7.) Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW. S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5(1):6.